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The aim of this study was to investigate the relationship between tumor budding (TB) and clinicopathologic prognostic criteria in colorectal adenocarcinomas and to discuss the inclusion of the fourth group in the scoring system. A total of 131 cases were included in the study. TB was scored according to the classical 3‐tiered scoring system and our proposed 4‐tiered scoring system: BD0 (no buds),...
Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID‐19. Few studies have investigated regulators of iron metabolism in the context of COVID‐19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community‐acquired pneumonia (CAP) caused by SARS‐CoV‐2 compared with CAP caused by bacteria or influenza virus in hospitalized...
Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients. To improve efficiency in antifungal drug development, we utilized a library of 1280 biologically active molecules...
Tumor infiltrating lymphocytes (TILs) have predictive and prognostic potential in HER2‐positive breast cancer (HER2 + BC). Due to tumor heterogeneity, guidelines recommend evaluation on full tumor‐sections over biopsies, but aren't clear regarding tissue microarrays (TMAs). Herein, we investigate the inter‐observer agreement of TILs assessment in HER2 + BC on full‐sections and TMAs using a standardized...
Methicillin‐resistant Staphylococcus aureus (MRSA) is resistant to almost all β‐lactam antibiotics. Hence, new ways to control MRSA infection, such as antibacterial antibodies, need to be explored. α‐hemolysin is the most important virulence factor widely expressed in S. aureus. This study aimed to develop a new fully human antibody against α‐hemolysin of S. aureus and research its neutralizing effect...
Sinonasal intestinal‐type adenocarcinoma (sITAC) is histomorphologically indistinguishable from colorectal adenocarcinoma (CRC) leading to diagnostic challenges. Metastases from CRCs to the sinonasal tract have been reported. The aim of the study was to identify a biomarker making it possible to distinguish between sITAC and metastases of colorectal origin. Formalin‐fixated paraffin‐embedded (FFPE)...
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